If you’re experiencing ongoing fatigue despite normal blood work, your gut health may play a role. When the intestinal barrier becomes more permeable, bacterial molecules called lipopolysaccharides (LPS) can enter the bloodstream and trigger low-grade inflammation. This immune response has been linked to fatigue, brain fog, poor concentration, and muscle aches in some people. While gut health is unlikely to be the only cause of chronic fatigue, it may be one contributing factor. Eating a fibre-rich diet, managing stress, staying active, sleeping well, and discussing persistent digestive symptoms with your healthcare provider may help support overall health and energy.