Autoinflammatory diseases are rare disorders caused by overactivity of the innate immune system, leading to recurring inflammation without infection. Symptoms may include recurrent fevers, joint and muscle pain, skin rashes, abdominal pain, and fatigue. Medical management is essential to control inflammation and prevent complications. While chiropractic care, physiotherapy, acupuncture, or massage therapy does not treat the underlying immune disorder, it may help manage secondary musculoskeletal symptoms such as joint stiffness, reduced mobility, and mechanical pain. As part of a coordinated healthcare team, individualized multidisciplinary care can support mobility, improve function, and enhance quality of life for people living with autoinflammatory diseases.